Pantula Rama was born into a family with a lineage of music. Her parents are Pantula Gopala Rao (Violinist and retired All India Radio engineer) and Pantula Padmavathi a veena artiste. She holds a Ph.D. in music from Andhra University for her thesis: A study of the shaping of an ideal musician through saadhana, published by Gyan Publishers of New Delhi.[3] She has an MA and BA in music from Andhra University, where she won gold medals each time and has been a University Topper. Her initial training was given to her by her father, and advanced training under Sangeeta Kalasagara Ivaturi Vijayeswara Rao. Apart from being a Top grade Vocalist, she has a B High in violin and viola from All India Radio in the carnatic style. She is an active fund raiser for events based on social and philanthropic causes.